Deoxypyridinoline – ascertaining increased bone loss

Deoxypyridinoline, also known as cross-links or Pyrilinks, causes a cross-linking of fibrillar collagens. In cases of increased osteoclast activity, increased amounts of deoxypyridinoline are released and eliminated renally, whereby there is a high correlation between deoxypyridinoline excretion and the bone resorption rate.

Indication for deoxypyridinoline determination:

Ascertaining increased bone breakdown in:

  • Primary hyperparathyroidism
  • Bone metastases
  • Paget's disease
  • Plasmacytoma
  • Influence of glucocorticoids, thyroxine

Ascertaining postmenopausal osteoporosis and monitoring its therapy.
Evidence of increased bone loss due to arthritis.

Test material

10 ml of morning urine without other additives

Reference ranges
Women: < 7.4 nmol/mmol creatinine
Men: < 5.4 nmol/mmol creatinine

Results above these limit values indicate increased bone resorption.